Original Papers


  • Ali A, Abouleila Y, Shimizu Y, Hiyama E, Watanabe TM, Yanagida T, Germond A
    “Single-Cell Screening of Tamoxifen Abundance and Effect Using Mass Spectrometry and Raman-Spectroscopy”
    Anal Chem, 91(4):2710, 2019
  • Shima T, Morikawa M, Kaneshiro J, Kambara T, Kamimura S, Yagi T, Iwamoto H, Uemura S, “Shigematsu H, Shirouzu M, Ichimura T, Watanabe TM, Nitta R, Okada Y, Hirokawa N
    “Kinesin-binding-triggered conformation switching of microtubules contributes to polarized transport ”
    J Cell Biol, 217(12):4164-4183, 2018
  • Germond A, Ichimura T, Horinouchi T, Fujita H, Furusawa C, Watanabe TM
    “Raman spectral signature reflects transcriptomic features of antibiotic resistance in Escherichia coli”
    Commun Biol, 1:85, 2018
  • Okamoto K, Germond A, Fujita H, Furusawa C, Okada Y, Watanabe TM
    “Single cell analysis reveals a biophysical aspect of collective cell-state transition in embryonic stem cell differentiation”
    Sci Rep, 8(1):11965, 2018
  • Germond A, Ichimura T, Chiu LD, Fujita K, Watanabe TM, Fujita H
    “Cell type discrimination based on image features of molecular component distribution”
    Sci Rep, 8(1):11726, 2018
  • Panina Y, Germond A, Masui S, Watanabe TM
    “Validation of Common Housekeeping Genes as Reference for qPCR Gene Expression Analysis During iPS Reprogramming Process”
    Sci Rep, 8(1):8716, 2018
  • Shiina T, Toi M, Yagi T
    “Development and clinical translation of photoacoustic mammography”
    Biomed Eng Lett, 8(2):157-165, 2018


  • Sato R, Kawashima R, Trinh MDL, Nakano M, Nagai T, Masuda S
    “Significance of PGR5-dependent cyclic electron flow for optimizing the rate of ATP synthesis and consumption in Arabidopsis chloroplasts”
    Photosynth Res, 139(1-3):359-365, 2019
  • Nezu A, Morita T, Nagai T, Tanimura A
    “Simultaneous monitoring of Ca2+ responses and salivary secretion in live animals reveals a threshold intracellular Ca2+ concentration for salivation”
    Exp Physiol, 104(1):61-69, 2019
  • Shinoda H, Ma Y, Nakashima R, Sakurai K, Matsuda T, Nagai T
    “Acid-Tolerant Monomeric GFP from Olindias Formosa”
    Cell Chem Biol, 25(3):330-338.e7, 2018
  • Maeshima K, Matsuda T, Shindo Y, Imamura H, Tamura S, Imai R, Kawakami S, Nagashima , Soga T, Noji H, Oka K, Nagai T
    “A Transient Rise in Free Mg2+ Ions Released from ATP-Mg Hydrolysis Contributes to Mitotic Chromosome Condensation”
    Curr Biol, 28(3):444-451.e6, 2018
  • Kushida Y, Arai Y, Shimono K, Nagai T
    “Biomimetic Chemical Sensing by Fluorescence Signals Using a Virus-like Particle-Based Platform”
    ACS Sens, 3(1):87-92, 2018
  • Wazawa T, Arai Y, Kawahara Y, Takauchi H, Washio T, Nagai T
    “Highly biocompatible super-resolution fluorescence imaging using the fast photoswitching fluorescent protein Kohinoor and SPoD-ExPAN with Lp-regularized image reconstruction”
    Microscopy (Oxf), 67(2):89-98, 2018
  • Ohta Y, Furuta T, Nagai T, Horikawa K
    “Red fluorescent cAMP indicator with increased affinity and expanded dynamic range”
    Sci Rep, 8(1):1866, 2018
  • Hossain MN, Suzuki K, Iwano M, Matsuda T, Nagai T
    “Bioluminescent Low-Affinity Ca2+ Indicator for ER with Multicolor Calcium Imaging in Single Living Cells”
    ACS Chem Biol, 13(7):1862-1871, 2018
  • Hara-Kuge S, Nishihara T, Matsuda T, Kitazono T, Teramoto T, Nagai T, Ishihara T
    “An improved inverse-type Ca2+ indicator can detect putative neuronal inhibition in Caenorhabditis elegans by increasing signal intensity upon Ca2+ decrease”
    PLoS One, 13(4):e0194707, 2018
  • Riani YD, Matsuda T, Takemoto K, Nagai T
    “Green monomeric photosensitizing fluorescent protein for photo-inducible protein inactivation and cell ablation”
    BMC Biol, 16(1):50, 2018
  • Suzuki K, Onishi T, Nakada C, Takei S, Daniels MJ, Nakano M, Matsuda T, Nagai T
    “Uninterrupted monitoring of drug effects in human-induced pluripotent stem cell-derived cardiomyocytes with bioluminescence Ca2+ microscopy”
    BMC Res Notes, 11(1):313, 2018
  • Komatsu N, Terai K, Imanishi A, Kamioka Y, Sumiyama K, Jin T, Okada Y, Nagai T, Matsuda M
    “A platform of BRET-FRET hybrid biosensors for optogenetics, chemical screening, and in vivo imaging”
    Sci Rep, 8(1):8984, 2018
  • Arai Y, Takauchi H, Ogami Y, Fujiwara S, Nakano M, Matsuda T, Nagai T
    “Spontaneously Blinking Fluorescent Protein for Simple Single Laser Super-Resolution Live Cell Imaging”
    ACS Chem Biol, 13(8):1938-1943, 2018
  • Shinoda H, Shannon M, Nagai T
    “Fluorescent Proteins for Investigating Biological Events in Acidic Environments”
    Int J Mol Sci, 19(6). pii: E1548, 2018
  • Li Q, Yoshimura H, Komiya M, Tajiri K, Uesugi M, Hata Y, Ozawa T
    “A robust split-luciferase-based cell fusion screening for discovering myogenesis-promoting molecules”
    Analyst, 143(14):3472-3480, 2018
  • Pavlou A, Yoshimura H, Aono S, Pinakoulaki E
    “Protein Dynamics of the Sensor Protein HemAT as Probed by Time-Resolved Step-Scan FTIR Spectroscopy”
    Biophys J, 114(3):584-591, 2018
  • Takenouchi O, Yoshimura H, Ozawa T
    “Unique Roles of β-Arrestin in GPCR Trafficking Revealed by Photoinducible Dimerizers”
    Sci Rep, 8(1):677, 2018
  • Yoshimura H
    “Live Cell Imaging of Endogenous RNAs Using Pumilio Homology Domain Mutants: Principles and Applications”
    Biochemistry, 57(2):200-208, 2018
  • Yoshimura H, Ozawa T
    “Real-Time Fluorescence Imaging of Single-Molecule Endogenous Noncoding RNA in Living Cells”
    Methods Mol Biol, 1649:337-347,2018


  • Miyamoto C, Kojo S, Yamashita M, Moro K, Lacaud G, Shiroguchi K, Taniuchi I, Ebihara T
    “Runx/Cbfβ complexes protect group 2 innate lymphoid cells from exhausted-like hyporesponsiveness during allergic airway inflammation”
    Nat Commun,10(1):447, 2019


  • Imakubo M, Takayama J, Onami S
    “Improvement and evaluation of a mathematical model for fertilization calucium waves in Ceanorhabditis elegans ”
    IPSJ Transactions on Bioinformatics, 11: 24-30, 2018
  • Onoue Y, Kyoda K, Kioka M, Baba K, Onami S, Koyamada K
    “Development of an integrated visualization system for phenotype character networks”
    IEEE Pacific Visualization Symposium (PacificVis 2018): 21-25, 2018


  • Bannai H, Hirose M, Niwa F, Mikoshiba, K
    “Dissection of Local Ca2+ Signals in Cultured Cells by Membrane-targeted Ca2+ Indicators”
    J Vis Exp, 145: e59246, 2019
  • Hiroshima M, Pack CG, Kaizu K, Takahashi K, Ueda M, Sako Y
    “Transient Acceleration of Epidermal Growth Factor Receptor Dynamics Produces Higher-Order Signaling Clusters”
    J Mol Biol, 430(9):1386-1401,2018
  • Yasui M, Hiroshima M, Kozuka J, Sako Y, Ueda M
    “Automated single-molecule imaging in living cells”
    Nat Commun, 9(1):3061, 2018
  • Yanagawa M, Hiroshima M, Togashi Y, Abe M, Yamashita T, Shichida Y, Murata M, Ueda M, Sako Y
    “Single-molecule diffusion-based estimation of ligand effects on G protein-coupled receptors”
    Sci Signal, 11(548). pii: eaao1917, 2018
  • Bannai H
    “Molecular membrane dynamics: Insights into synaptic function and neuropathological disease”
    Neurosci Res, 129: 47-56, 2018


  • Morishima M, Horikawa K, Funaki M
    “Cardiomyocytes cultured on mechanically compliant substrates, but not on conventional culture devices, exhibit prominent mitochondrial dysfunction due to reactive oxygen species and insulin resistance under high glucose”
    PLoS One, 13(8):e0201891,2018
  • Tanihara F, Hirata M, Nguyen NT, Le QA, Hirano T, Takemoto T, Nakai M, Fuchimoto DI, Otoi T
    “Generation of PDX-1 mutant porcine blastocysts by introducing CRISPR/Cas9-system into porcine zygotes via electroporation”
    Anim Sci J, 90(1):55-61, 2019
  • Tanihara F, Hirata M, Nguyen NT, Le QA, Hirano T, Takemoto T, Nakai M, Fuchimoto DI, Otoi T
    “Generation of a TP53-modified porcine cancer model by CRISPR/Cas9-mediated gene modification in porcine zygotes via electroporation”
    PLoS One, 13(10):e0206360, 2018
  • Harada A, Maehara K, Ono Y, Taguchi H, Yoshioka K, Kitajima Y, Xie Y, Sato Y, Iwasaki T, “Nogami J, Okada S, Komatsu T, Semba Y, Takemoto T, Kimura H, Kurumizaka H, Ohkawa Y
    Histone H3.3 sub-variant H3mm7 is required for normal skeletal muscle regeneration”
    Nat Commun, 9(1):1400, 2018
  • Nishio K, Tanihara F, Nguyen TV, Kunihara T, Nii M, Hirata M, Takemoto T, Otoi T
    “Effects of voltage strength during electroporation on the development and quality of in vitro-produced porcine embryos”
    Reprod Domest Anim, 53(2):313-318, 2018


  • Li J, Hashimoto H, Meltzer HY
    “Association of Serotonin2c Receptor Polymorphisms With Antipsychotic Drug Response in Schizophrenia”
    Front Psychiatry, 10:58, 2019
  • Ivic I, Balasko M, Fulop BD, Hashimoto H, Toth G, Tamas A, Juhasz T, Koller A, Reglodi D, Solymár M
    “VPAC1 receptors play a dominant role in PACAP-induced vasorelaxation in female mice”
    PLoS One, 14(1):e0211433, 2019
  • Kawase H, Ago Y, Naito M, Higuchi M, Hara Y, Hasebe S, Tsukada S, Kasai A, Nakazawa T, Mishina T, Kouji H, Takuma K, Hashimoto H
    “mS-11, a mimetic of the mSin3-binding helix in NRSF, ameliorates social interaction deficits in a prenatal valproic acid-induced autism mouse model”
    Pharmacol Biochem Behav, 176:1-5, 2019
  • Nishitani N, Nagayasu K, Asaoka N, Yamashiro M, Andoh C, Nagai Y, Kinoshita H, Kawai H, Shibui N, Liu B, Hewinson J, Shirakawa H, Nakagawa T, Hashimoto H, Kasparov S, Kaneko S
    “Manipulation of dorsal raphe serotonergic neurons modulates active coping to inescapable stress and anxiety-related behaviors in mice and rats”
    44(4):721-732, 2019


  • Maeda TK, Sugiura D, Okazaki IM, Maruhashi T, Okazaki T
    “Atypical motifs in the cytoplasmic region of the inhibitory immune co-receptor LAG-3 inhibit T cell activation”
    J Biol Chem, RA119.007455, 2019
  • Mizuno R, Maruhashi T, Sugiura D, Shimizu K, Watada M, Okazaki IM, Okazaki T
    “PD-1 efficiently inhibits T cell activation even in the presence of co-stimulation through CD27 and GITR”
    Biochem Biophys Res Commun, S0006-291X(19)30183-4, 2019
  • Takeuchi A, Ozawa M, Kanda Y, Kozai M, Ohigashi I, Kurosawa Y, Rahman MA, Kawamura T, “Shichida Y, Umemoto E, Miyasaka M, Ludewig B, Takahama Y, Nagasawa T, Katakai T
    A Distinct Subset of Fibroblastic Stromal Cells Constitutes the Cortex-Medulla Boundary Subcompartment of the Lymph Node”
    Front Immunol, 9:2196, 2019
  • Maruhashi T, Okazaki IM, Sugiura D, Takahashi S, Maeda TK, Shimizu K, Okazaki T
    “LAG-3 inhibits the activation of CD4+ T cells that recognize stable pMHCII through its conformation-dependent recognition of pMHCII”
    Nat Immunol, 19(12):1415-1426,2018
  • Bogdanova D, Takeuchi A, Ozawa M, Kanda Y, Rahman MA, Ludewig B, Kinashi T, Katakai T
    “Essential Role of Canonical NF-κB Activity in the Development of Stromal Cell Subsets in Secondary Lymphoid Organs”
    J Immunol, 201(12): 3580-3586, 2018
  • Kanda Y, Takeuchi A, Ozawa M, Kurosawa Y, Kawamura T, Bogdanova D, Iioka H, Kondo E, Kitazawa Y, Ueta H, Matsuno K, Kinashi T, Katakai T
    “Visualizing the Rapid and Dynamic Elimination of Allogeneic T Cells in Secondary Lymphoid Organs”
    J Immunol,201(3):1062-1072, 2018
  • Katakai T
    “Live Imaging of Interstitial T Cell Migration Using Lymph Node Slices”
    Methods Mol Biol, 1763:29-42, 2018