Identification and characterization of psychiatric disorder-related singularity cells with high-speed and high-resolution whole-brain imaging
Name: Hitoshi Hashimoto
Affiliation: Graduate School of Pharmaceutical Sciences, Osaka University
Major: Laboratory of Molecular Neuropharmacology
Role: Technical development and application of whole-brain imaging with single-cell resolution
Neurons of the mammalian central nervous system are highly diverse in their development, structure, size, electrophysiological properties, function and molecular composition. In this study, we develop and apply high-speed and scalable whole-brain imaging with single-cell resolution for large-scale cells across various brain regions to analyze the molecular pathophysiology of psychiatric disorders in iPSC-derived neurons from patients and mouse disease models and to identify and characterize the psychiatric disorder-related singularity cells. We also provide evidence-based data for singularity biology-related new therapeutic approaches in psychiatric disorders.