A03-3

Identification and characterization of psychiatric disorder-related singularity cells with high-speed and high-resolution whole-brain imaging


Name: Hitoshi Hashimoto
Affiliation: Graduate School of Pharmaceutical Sciences, Osaka University
Major: Laboratory of Molecular Neuropharmacology
Role: Technical development and application of whole-brain imaging with single-cell resolution


Purpose:
Neurons of the mammalian central nervous system are highly diverse in their development, structure, size, electrophysiological properties, function and molecular composition. In this study, we develop and apply high-speed and scalable whole-brain imaging with single-cell resolution for large-scale cells across various brain regions to analyze the molecular pathophysiology of psychiatric disorders in iPSC-derived neurons from patients and mouse disease models and to identify and characterize the psychiatric disorder-related singularity cells. We also provide evidence-based data for singularity biology-related new therapeutic approaches in psychiatric disorders.



Name: Takanobu Nakazawa
Affiliation: Graduate School of Dentistry, Osaka University
Major: Department of Pharmacology
Role: Modeling psychiatric disorders with iPSC technologies and mouse models