Singularity cells in immunity and cancer development.
Upon invasion of pathogens, dendritic cells capture and process antigens, move to lymphnodes, and present antigen to T cells. T cells are not readily activated upon recognition of their cognate antigen on dendritic cells but only T cells that meet various spacio-temporal and stochastic conditions are properly activated to mount optimal immune responses. Recent progress in cancer immunotherapy revealed that cancer cells acquire immune-evasion potential in tumor development or metastasis. However, the mechanisms how cancer cells acquire immune-evasion potential are not well understood. In the current project, we focus on autoimmunity, cancer immunity, tumor development, and metastasis that can be regarded as singularity events and aim to identify and characterize “signularity cells” that play pivotal roles in these singular events.