Original Papers

Singularity Biology Outcome Database in SSBD

SSBD, a database operated by the A02-1 Onami Group, provides a database of the results of Singularity Biology. This database contains original papers, review articles, and related open data sets obtained from the Singularity Biology research.
Papers are selected mainly from PubMed and PMC based on 1) grant numbers, 2) researchers’ names and affiliations, and information such as research groups are assigned and provided with links to the SSBD data.
Currently, information on 2,265 papers (including papers published in the phase of preparing the Singularity Biology) and 50 projects have been collected. We are still accepting requests for data release.

How to use SSBD Singularity Database
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Original Papers: 959 in total (2018 June ~ 2023 March)

<Representative Papers from each research group>

A01-1 Watanabe Group　 70 papers

  1. Kaneshiro J, Shioi G, Okamoto K, Onami S, *Watanabe TM. “Improvement in image quality via the pseudo confocal effect in multidirectional digital scanned laser light-sheet microscopy.” Opt Express29: 24278-24288 (2021).
  2. *Mizushima R, Inoue K, Fujiwara H, Iwane AH, *Watanabe TM, *Kimura A. “Multiplexed 129Xe HyperCEST MRI Detection of Genetically Reconstituted Bacterial Protein Nanoparticles in Human Cancer Cells.” Contrast Media Mol Imaging12: 2020:5425934 (2020).
  3. Matsumoto K, Mitani TT, Horiguchi SA, Kaneshiro J, Murakami TC, Mano T, Fujishima H, Konno A, Watanabe TM, Hirai H, *Ueda HR. ”Advanced CUBIC tissue clearing for whole-organ cell profiling.” Nat Protoc14: 3506-37 (2019).
  4. Kaneshiro J, Okada Y, Shima T, Tsujii M, Imada K, Ichimura T, *Watanabe TM. “Second harmonic generation polarization microscopy as a tool for protein structure analysis.” Biophys Physicobiol16: 147-57 (2019).
  5. Nishiyama M, Namita T, Kondo K, Yamakawa M, *Shiina T.“Ring-array photoacoustic tomography for imaging human finger vasculature.” J Biomed Opt24: 1-12 (2019).

A01-2 Nagai Group　80 papers

  1. Ichimura T, Kakizuka T, Horikawa K, Seiriki K, Kasai A, Hashimoto H, Fujita K, Watanabe TM, *Nagai T. “Exploring rare cellular activity in more than one million cells by a transscale scope.” Sci Rep11: 16539 (2021).
  2. Shinoda H, Kai L, Nakashima R, Wazawa T, Noguchi K, Matsuda T, *Nagai T. “Acid-Tolerant Reversibly Switchable Green Fluorescent Protein for Super-resolution Imaging under Acidic Conditions.” Cell Chem Biol 26: 1469-79 (2019).
  3. Oketani R, Suda H, Uegaki K, Kubo T, Matsuda T, Yamanaka M, Arai Y, Smith N, Nagai T, *Fujita K. “Visible-wavelength two-photon excitation microscopy with multifocus scanning for volumetric live-cell imaging.” Biomed. Opt. 25: 014502 (2019).
  4. Endo M, Iwawaki T, Yoshimura H, *Ozawa T. “Photocleavable Cadherin Inhibits Cell-to-cell Mechanotransduction by Light.”ACS Chem Biol 14: 2206-14 (2019).
  5. Takenouchi O, Yoshimura H, *Ozawa T. “Unique Roles of β-Arrestin in GPCR Trafficking Revealed by Photoinducible Dimerizers.” Sci Rep 8: 677 (2018).

A01-3 Shiroguchi Group　12 papers

  1. Jin J§, Ogawa T§, Hojo N, Kryukov K, Shimizu K, Ikawa T, Imanishi T, Okazaki T, *Shiroguchi K. (§equally contributed) “Robotic data acquisition with deep learning enables cell image-based prediction of transcriptomic phenotypes” Proc Natl Acad. SciU S A 120 (1): e2210283120 (2022).
  2. Jin J, Yamamoto R, Takeuchi T, Cui G, Miyauchi E, Hojo N, Ikuta K, Ohno H, *Shiroguchi K. “High-throughput identification and quantification of single bacterial cells in the microbiota.” Nat Commun13: 863 (2022).
  3. *Kimura S, Nakamura Y, Kobayashi N, Shiroguchi K, Kawakami E, Mutoh M, Takahashi-Iwanaga H, Yamada T, Hisamoto M, Nakamura M, Udagawa N, Sato S, Kaisho T, Iwanaga T, *Hase K. “Osteoprotegerin-dependent M cell self-regulation balances gut infection and immunity.” Nat Commun11:234 (2020).
  4. Miyamoto C, Kojo S, Yamashita M, Moro K, Lacaud G, Shiroguchi K, Taniuchi I, *Ebihara T. “Runx/Cbfβ complexes protect group 2 innate lymphoid cells from exhausted-like hyporesponsiveness during allergic airway inflammation.” Nat Commun10:447 (2019).

A02-1Onami Group 19 Papers

  1. Nozaki T, Shinkai S, Ide S, Higashi K, Tamura S, Shimazoe MA, Nakagawa M, Suzuki Y., Okada Y, Sasai M, Onami S, Kurokawa K, Iida S, *Maeshima K.“Condensed but liquid-like domain organization of active chromatin regions in living human cells.”Sci Adv11, eadf1488 (2023).
  2. Kyoda K, Ho KHL, Itoga H, Tohsato Y, *Onami S. ”BD5: an open HDF5-based data format to represent quantitative biological dynamics data.” bioRxiv (2020).
  3. *Shinkai S, Nakagawa M, Sugawara T, Togashi Y, Ochiai H, Nakato R, Taniguchi Y, *Onami S. ”PHi-C: deciphering Hi-C data into polymer dynamics.”NAR Genom Bioinform2: lqaa020(2020).
  4. *Shinkai S, Sugawara T, Miura H, Hiratani I, *Onami S. ”Michrorheology for Hi-C data reveals the spectrum of the dynamic 3D genome organization.” Biophys J118: 2220-8(2020).
  5. Onoue Y, Kyoda K, Kioka M, Baba K, Onami S, *Koyamada K. ” Development of an integrated visualization system for phenotype character networks.” IEEE Pacific Visualization Symposium21-5 (2018).

A02-2 Komatsuzaki Group　57 papers

  1. Sattari S, Basak U, James R, Perrin L, Crutchfield J, *Komatsuzaki T. “Modes of information flow in collective cohesion.” Sci Adv, 8: 6 (2022).
  2. Basak US, Sattari S, Horikawa K, *Komatsuzaki T. Inferring Domain of Interactions among Particles from Ensemble of Trajectories.  Rev. E, Accepted (2020).
  3. Tabata K, *Nakamura A, Honda J, Komatsuzaki T, “A bad arm existence checking problem: How to utilize asymmetric problem structure?”Mach Learn 109: 327-72 (2020).
  4. *Komatsuzaki T, *Pressé S, *Senet P “Deciphering Molecular Complexity in Dynamics and Kinetics – From the Single Molecule to the Single Cell Level.” J Phys Chem B 123: 6387-88 (2019).
  5. Helal KM, Taylor JN, Cahyadi H, Okajima A, Tabata K, Itoh Y, Tanaka H, Fujita K, *Harada Y, *Komatsuzaki T. “Raman spectroscopic histology using machine learning for nonalcoholic fatty liver disease.” FEBS Lett 593: 2535–44 (2019).

A03-1Bannai Group 35 Papers

  1. Okuzumi, A, Hatano, T, Matsumoto, G, Nojiri, S, Ueno, S, Imamichi Y, Kimura, H, Kakuta, S, Kondo, A, Fukuhara, T, Li, Y, Funayama, M, Saiki, S, Taniguchi, D, Tsunemi, T, McIntyre, D, Gérardy, J, Mittelbronn, M, Krüger, R, Uchiyama, Y, Nukina, N, *Hattori, N.“Propagative α-synuclein seeds as serum biomarkers for synucleinopathies.”Nat Medicine 29, 1448–1455 (2023).
  2. *Hiroshima M, Yasui M, Ueda M. “Large-scale single-molecule imaging aided by artificial intelligence.” Microscopy (Oxf)69: 69-78, (2020).
  3. *Bannai H, Niwa F, Sakuragi S, Mikoshiba K. “Inhibitory synaptic transmission tuned by Ca2+and glutamate through the control of GABAAR lateral diffusion dynamics.” Dev Growth Differorg/10.1111/dgd.12667 (2020).
  4. Soeda Y, Saito M, Maeda S, Ishida K, Nakamura A, Kojima S, *Takashima A. “Methylene blue inhibits formation of tau fibrils but not of granular tau oligomers: A plausible key to understanding failure of a clinical trial for Alzheimer’s disease.” J Alzheimers Dis68:1677-86 (2019).

A03-2 Horikawa Group　31 Papers

  1. Maruhashi T, Sugiura D, Okazaki IM, Shimizu K, Maeda TK, Ikubo J, Yoshikawa H, Maenaka K, Ishimaru N, Kosako H, Takemoto T, *Okazaki T. “Binding of LAG-3 to stable peptide-MHC class II limits T cell function and suppresses autoimmunity and anti-cancer immunity.” Immunity 55(5): 912-924 (2022).
  2. Kakizuka T, Hara Y, OhtaY, Mukai A, Ichiraku A,AraiY, Ichimura T,NagaiT, *Horikawa K., Cellular logics bringing the symmetry breaking in spiral nucleation revealed by trans-scale imaging. bioRxiv, doi:10.1101/2020.06.29.176891 (2020).
  3. Iida H, Furukawa Y, Teramoto M, Suzuki H, Takemoto T, Uchikawa M, *Kondoh H. “Sox2 gene regulation via the D1 enhancer in embryonic neural tube and neural crest by the combined action of SOX2 and ZIC2.” Genes Cells25:242-56 (2020).
  4. Yamamoto S, Uchida Y, Ohtani T, Nozaki E, Yin C, Gotoh Y, Yakushiji‐Kaminatsui N, Higashiyama T, Suzuki T, Takemoto T, Shiraishi Y, *Kuroiwa A “Hoxa13 regulates expression of common Hox target genes involved in cartilage development to coordinate the expansion of the autopodal anlage.” Dev Growth Differ61:228-51 (2019).
  5. Morishima M, Horikawa K. *Funaki M. “Cardiomyocytes cultured on mechanically compliant substrates, but not on conventional culture devices, exhibit prominent mitochondrial dysfunction due to reactive oxygen species and insulin resistance under high glucose.” PLoS One 13: e0201891 (2018).

A03-3 Hashimoto Group　48 Papers

  1. Nagai Y, Kisaka Y, Nomura K, Nishitani N, Andoh C, Koda M, Kawai H, Seiriki K, *Nagayasu K, Kasai A, Shirakawa H, Nakazawa T, Hashimoto H, *Kaneko S. “Dorsal raphe serotonergic neurons preferentially reactivate dorsal dentate gyrus cell ensembles associated with positive experience.” Cell Rep42: 112149 (2023).
  2. Kawano S, Baba M, Fukushima H, Miura D, Hashimoto H, Nakazawa T. “Autism-associated ANK2 regulates embryonic neurodevelopment.” Biochem Biophys ResCommun 605:45-50 (2022).
  3. Tanuma M, *Kasai A, Bando K, Kotoku N, Harada K, Minoshima M, Higashino K, Kimishima A, Arai M, Ago Y, Seiriki K, Kikuchi K, Kawata S, Fujita K, *Hashimoto H. “Direct visualization of an antidepressant analog using surface-enhanced Raman scattering in the brain.” JCI Insight, 5:e133348 (2020).
  4. Matsumura K, Seiriki K, Okada S, Nagase M, Ayabe S, Yamada I, Furuse T, Shibuya H, Yasuda Y, Yamamori H, Fujimoto M, Nagayasu K, Yamamoto K, Kitagawa K, Miura H, Gotoda-Nishimura N, Igarashi H, Hayashida M, Baba M, Kondo M, Hasebe S, Ueshima K, Kasai A, Ago Y, Hayata-Takano A, Shintani N, Iguchi T, Sato M, Tamura M, Wakana S, Yoshiki A, Watabe AM, Okano H, Takuma K, Hashimoto R, *Hashimoto H, *Nakazawa T. “Pathogenic POGZ mutation causes impaired cortical development and reversible autism-like phenotypes.” Nat Commun 11: 859 (2020).
  5. Seiriki K, *Kasai A, Nakazawa T, Niu M, Naka Y, Tanuma M, Igarashi H, Yamaura K, Hayata-Takano A, Ago Y, *Hashimoto H. ”Whole-brain block-face serial microscopy tomography at subcellular resolution using FAST.” Nat Protoc 14: 1509-29 (2019).

A03-4 Okazaki Group　52 Papers

  1. Sugiura D, Okazaki IM, Maeda TK, Maruhashi T, Shimizu K, Arakaki R, Takemoto T, Ishimaru N, *Okazaki T. “PD-1 agonism by anti-CD80 inhibits T cell activation and alleviates autoimmunity.” Nat Immun23: 399-410 (2022).
  2. Shimizu K, Sugiura D, Okazaki IM, Maruhashi T, Takegami Y, Cheng C, Ozaki S, *Okazaki T.“PD-1 imposes qualitative control of cellular transcriptomes in response to T cell activation.” Mol Cell 77: 937-50 (2020).
  3. Okamura H, Okazaki IM, Shimizu K, Maruhashi T, Sugiura D, Mizuno R, and *Okazaki T. “PD-1 aborts the activation trajectory of autoreactive CD8+T cells to prohibit their acquisition of effector functions.” J Autoimmun 105: 102296  (2019).
  4. Sugiura D, Maruhashi T, Okazaki IM, Shimizu K, Maeda TK, Takemoto T, and *Okazaki T. “Restriction of PD-1 function by cis-PD-L1/CD80 interactions is required for optimal T cell responses.” Science, 364: 558-66, (2019).
  5. Nagai M, Noguchi R, Takahashi D, Morikawa T, Koshida K, Komiyama S, Ishihara N, Yamada T, Kawamura YI, Muroi K, Hattori K, Kobayashi N, Fujimura Y, Hirota M, Matsumoto R, Aoki R, Tamura-Nakano M, Sugiyama M, Katakai T, Sato S, Takubo K, Dohi T, *Hase K. “Fasting-Refeeding Impacts Immune Cell Dynamics and Mucosal Immune Responses.”178: 1072-87, (2019).

Publicity Offered Group A01 152 papers

  1. *Hanaoka K, Iwaki S, Yagi K, Myochin T, Ikeno T, Ohno H, Sasaki E, Komatsu T, Ueno T, Uchigashima M, Mikuni T, Tainaka K, Tahara S, Takeuchi S, Tahara T, Uchiyama M, Nagano T, *Urano Y. “General design strategy to precisely control the emission of fluorophores via a twisted intramolecular charge transfer (TICT) process.” J Am Chem Soc144: 19778 (2022).
  2. Liu N, *Matsumura H, Kato T, Ichinose S, Takada A, Namiki T, Asakawa K, Morinaga H, Mohri Y, De Arcangelis A, Geroges-Labouesse E, *Nanba D, *Nishimura, EK. “Stem cell competition orchestrates skin homeostasis and ageing.” Nature568: 344-350 (2019).
  3. Orioka M, Eguchi M, Mizui Y, Ikeda Y, Sakama A, Li Q, *Yoshimura H, Ozawa T, Citterio D, *Hiruta Y. “A Series of Furimazine Derivatives for Sustained Live-cell Bioluminescence Imaging and Application to the Monitoring of Myogenesis at Single-cell Level.”  Chem., 33: 496-504 (2022).
  4. Hirasawa T, Tachi K, Miyashita M, Okawa S, Kushibiki T, *Ishihara M. “Spectroscopic photoacoustic microscopic imaging during single spatial scan using broadband excitation light pulses with wavelength-dependent time delay.” Photoacoustics26: 100364 (2022).
  5. Satoh AO, Fujioka Y, Kashiwagi S, Yoshida A, Fujioka M, Sasajima H, Nanbo A, Amano M, *Ohba Y. “Interaction between PI3K and the VDAC2 channel tethers Ras-PI3K-positive endosomes to mitochondria and promotes endosome maturation.” Cell Rep42: 112229 (2023).
  6. Ugawa M, *Ota S. “High-speed 3D imaging flow cytometry with optofluidic spatial transformation.” Biomed Opt Express13: 3647-3656 (2022).
  7. Jahan A, Akter MT, Takemoto K, Oura T, Shitara A, Semba S, Nezu A, Suto S, Nagai T, Tanimura A. “Insertion of circularly permuted cyan fluorescent protein into the ligand-binding domain of inositol 1,4,5-trisphosphate receptor for enhanced FRET upon binding of fluorescent ligand” Cell calcium108: 102668 (2022).
  8. Oe M, Suzuki K, Miki K, Mu H, Ohe K. “Steric Control in Activator-Induced Nucleophilic Quencher Detachment-Based Probes: High-Contrast Imaging of Aldehyde Dehydrogenase 1A1 in Cancer Stem Cells.”ChemPlusChem 87: e220200319 (2022).
  9. Hosokawa T, Tanaka S, Mori T, Baba Y, *Katayama Y “Quiescent B cells acquire sensitivity to cell cycle arresting agents by B cell receptor stimulation” Bio Pharm Bull45: 847-850 (2020).

Publicity Offered Group A02 25 Papers

  1. *冨樫 祐一, マイクロマシン集団の力学的相互干渉：「シンギュラリティ細胞」のモデルとして. 第64回システム制御情報学会研究発表講演会講演論文集(2020).
  2. Handa T, Harada A, Maehara K, Sato S, Nakao M, Goto N, Kurumizaka H, *Ohkawa Y, *Kimura H.“Kimura H.: Chromatin integration labeling for mapping DNA-binding proteins and modifications with low input.” Nat Protoc215: 3334-3360 (2020).
  3. Murata O, Shindo Y, Ikeda Y, Iwasawa N, *Citterio D, *Oka K, *Hiruta Y. “Near-Infrared Fluorescent Probes for Imaging of Intracellular Mg2+and Application to Multi-Color Imaging of Mg2+, ATP, and Mitochondrial Membrane Potential.” Anal Chem 92:966-74 (2020).

Publicity Offered Group A03 392 Papers

  1. Fujioka Y, Kashiwagi S, Yoshida A, Satoh AO, Fujioka M, Amano M, Yamauchi Y and Ohba Y. “A method for the generation of pseudovirus particles bearing SARS coronavirus spike protein in high yields.” Cell Struct Funct 47: 43-53 (2022).
  2. Jiang H, Kimura T, Hai H, Yamamura R, *Sonoshita M. “Drosophilaas a toolkit to tackle cancer and its metabolism.” Frontier Onco 12: 982751 (2022).
  3. Yoshizawa K, Matsura A, Shimada M, Ishida-Ishihara S, Sato F, Yamamoto T, Yaguchi K, Kawamoto E, Kuroda T, Matsuo K, Tamaoki N, Sakai R, Shimada Y, Mishra M, and *Uehara R. “Tetraploidy-linked sensitization to CENP-E inhibition in human cells” Mol OncoIn press (2023).
  4. Inoue M, Takeuchi A, Manita S, Horigane S-I, Sakamoto M, Kawakami R, Yamaguchi K, Otomo K, Yokoyama H, Kim R, Yokoyama T, Takemoto-Kimura S, Abe M, Okamura M, Kondo Y, Quirin S, Ramakrishnan C, Imamura T, Sakimura K, Nemoto T, Kano M, Fujii H, Deisseroth K, Kitamura K, *Bito H. “Rational engineering of XCaMPs, a multicolor GECI suite for in vivo imaging of complex brain circuit dynamics.” Cell177: 1346-1360 (2019).
  5. Arii J, Takeshima K, Maruzuru Y, Koyanagi N, Nakayama Y, Kato A, Mori Y, *Kawaguchi Y. “Role of the arginine cluster in the disordered domain of Herpes Simplex Virus 1 UL34 for the recruitment of ESCRT-III for viral primary envelopment.”  Virol 96: e0170421 (2022).
  6. Akutsu T, Mori T, Nakamura N, Kozawa S, Ueno Y, Sato TN. “On the complexity of tree edit distance with variables.” LPICS44: 1-14 (2022).
  7. Perez CAG, Adachi S, Nong QD, Adhitama N, Matsuura T, Natsume T, Wada T, Kato Y, Watanabe H. “Sense-overlapping lncRNA as a decoy of translational repressor protein for dimorphic gene expression.” PLoS Genet17: e1009683 (2021).
  8. Kalfaoglu B, Almeida-Santos J, Tye CA, Satou Y, *Ono M. “T-cell hyperactivation and paralysis in severe COVID-19 infection revealed by single-cell analysis.” bioRxiv05.26.115923 (2020).
  9. *Kubo M, Nagashima R, Kurihara M, Kawakami F, Maekawa T, Eshima K ,Ohta E, Kato H, Obata F. “Leucine-Rich Repeat Kinase 2 Controls Inflammatory Cytokines Production through NF-κB Phosphorylation and Antigen Presentation in Bone Marrow-Derived Dendritic Cells.” Int J Mol Sci21: 1890 (2020).
  10. Miyamoto K, Hayabuchi H, Tokifuji Y, Ando M, Onishi N, Okamura T, Yoshimura A, *Chikuma S　“A Protein Kinase D inhibitor suppresses AKT on T cells and antagonizes cancer immunotherapy by Anti-PD-1.”　Int Immunol16: dxac035 (2022).
  11. Akter E, Tasaki Y, Mori Y, Nakai K, Hachiya K, Lin H, Konno M, Kamasaki T, Tanabe K, Umeda Y, Yamano S, Fujita Y, *Kon S. “Non-degradable autophagic vacuoles are indispensable for cell competition.” Cell Rep40: 111292 (2022).
  12. Matsumoto R, Suga H, Aoi T, Bando H, Fukuoka H, Iguchi G, Narumi S, Hasegawa T, Muguruma K, Ogawa W, Takahashi Y. “Congenital pituitary hypoplasia model demonstrates hypothalamic OTX2 regulation pf pituitary progenitor cells.” J Clin Investi 130, 641-654 (2020).
  13. Shibata AC, Ueda HH, Eto K, Onda M, Sato A, Ohba T, Nabekura J, *Murakoshi H. “Photoactivatable CaMKII induces synaptic plasticity in single synapses.” Nat Commun12: 751 (2021).
  14. Uno W, Ofuji K, Wymeersch F. J, *Takasato, M. “In vitro induction of prostate buds from murine urogenital epithelium in the absence of mesenchymal cells.” Dev Biol498: 49–60 (2023).
  15. Maeda J, Minamihisamatsu T, Shimojo M, Zhou X, Ono M, Matsuba Y, Ji B, Ishii H, Ogawa M, Akatsu H, Kaneda D, Hashizume Y, Robinson JL, Lee VMY, Saito T, Saido TC, Troganowski JQ, Zhang MR, Suhara T, Higuchi M, *Sahara N. “Distinct microglial response against Alzheimer’s amyloid and tau pathologies characterized by P2Y12 receptor.” Brain Commun3: fcab011 (2021).
  16. Senoo H, Kamimura Y, Kimura R, Nakajima A, Sawai S, Sesaki H, *Iijima M “Phosphorylated Rho-GDP directly activates mTORC2 kinase towards AKT through dimerization with Ras-GTP to regulate cell migration.” Nat Cell Biol 21:867 – 78 (2019).
  17. Tsai C.J, Nagata T, Liu C, Suganuma T, Kanda T, Miyazaki T, Liu K, Saitoh T, Nagase H, Lazarus M, Vogt K, Yanagisawa M, *Hayashi Y. “Cerebral capillary blood flow upsurge during REM sleep is mediated by A2A receptors.” Cell Rep17: 109558 (2021).
  18. Maeda F, Kato A, Takeshima K, Shibazaki M, Sato R, Shibata T, Miyake K, Kozuka-Hata H, Oyama M, Shimizu E, Imoto S, Miyano S, Adachi S, Natsume T, Takeuchi K, Maruzuru Y, Koyanagi N, Arii J, *Kawaguchi Y. “Role of the Orphan Transporter SLC35E1 in the Nuclear Egress of Herpes Simplex Virus 1.”J Virol 96: e0030622 (2022).
  19. Tanno A, Tokutsu R, Arakaki Y, Ueki N, Minagawa J, Yoshimura K, Hisabori T, Nozaki H, *Wakabayashi K. “The four-celled Volvocales green alga Tetrabaena socialisexhibits weak photobehavior and high-photoprotection ability.” PLoS ONE 16: e0259138 (2021).
  20. Kato S, Maeda Y, Sugiyama D, Watanabe K, *Nishikawa H, *Hinohara K. “The cancer epigenome: Non-cell autonomous player in tumor immunity.” Cancer Sci114: 730-740 (2023).
  21. *Ono D, Wang H, Hung J.C, Wang T.H, Kon N, Yamanaka A, Li Y, Sugiyama T. “Network-driven intracellular cAMP coordinates circadian rhythm in the suprachiasmatic nucleus.” Sci Adv9: 1 (2023).
  22. *Enomoto M, Takemoto D, *Igaki T. “Interaction between Ras and Src clones causes interdependent tumor malignancy via Notch signaling in Drosophila.” Dev Cell56: 2223-2236 (2021).
  23. Oginuma M, Nishida M, Ohmura-Adachi T, Abe K, Ogamino S, Mogi C, Matsui N, *Ishitani T. “Rapid reverse genetics systems for Nothobranchius furzeri, a suitable model organism to study vertebrate aging.” Sci Rep12: 11628 (2022).
  24. Kobayashi A, Hamada M, Yoshida MA, Kobayashi Y, Tsutsui N, Sekiguchi T, Matsukawa Y, Maejima S, Gingell JJ, Sekiguchi S, Hamamoto A, Hay DL, Morris JF, Sakamoto T, *Sakamoto H. “Vasopressin-oxytocin-type signaling is ancient and has a conserved water homeostasis role in euryhaline marine planarians.” Sci Adv8: eabk0331 (2022).
  25. Kaneko R, Matsui A, Watanabe M, Harada Y, Kanamori M, Awata N, Kawazoe M, Takao T, Kobayashi Y, Kikutake C, Suyama M, Saito T, Saido TC, *Ito M. “Increased neutrophils in inflammatory bowel disease accelerate the accumulation of amyloid plaques in the mouse model of Alzheimer’s disease.” Inflamm Regenerat43(1): 20 (2023).
  26. *Koyanagi M, Shen B, Nagata T, Sun L, Wada S, Kamimura S, Kage-Nakadai E, *Terakita A. “High-performance optical control of GPCR signaling by bistable animal opsins MosOpn3 and LamPP in a molecular property-dependent manner.” Proc Natl Acad. SciU S A 119: e2204341119 (2022).
  27. Imaizumi K, Ideno H, Sato T, Morimoto S, *Okano H. “Pathogenic Mutation of TDP-43 Impairs RNA Processing in a Cell Type-Specific Manner: Implications for the Pathogenesis of ALS/FTLD.” eNeuro9 (2022).
  28. Kogure YS, Muraoka H, Koizumi WC, Gelin-Alessi R, Godard B, Oka K, Heisenberg CP, *Hotta K. “Admp regulates tail bending by controlling ventral epidermal cell polarity via phosphorylated myosin localization in Ciona.” Development149: dev200215 (2022).
  29. Matsushita N, Nishizawa K, Kato S, Iguchi Y, Fukabori R, *Takeuchi K, *Kobayashi K “Catecholaminergic cell type-specific expression of Cre recombinase in knock-in transgenic rats generated by the Combi-CRISPR technology.” J Neurosci Method381: 109707 (2022).
  30. Inami S1,Sato T1, Kurata Y, Suzuki Y, Kitamoto T, and *Sakai T. “Consolidation and maintenance of long-term memory involves dual functions of the developmental regulator Apterous in clock neurons and mushroom bodies in the Drosophila” PLoS Biol19: e3001459 (2021).
  31. Yoshiko K, Kato K, Iida H, Teramoto M, Kawamura A, Watanabe Y, Nunome M, Nakano M, Matsuda Y, Sato Y, Mizuno H, Iwasato T, Ishii Y, *Kondoh H. “Live imaging of avian epiblast and anterior mesendoderm grafting reveals the complexity of cell dynamics during early brain development.” Development149: dev199999 (2022).
  32. Kanazawa Y, *Omotehara T, Nakata H, Hirashima T, Itoh M “Three-dimensional analysis and in vivo imaging for sperm release and transport in the murine seminiferous tubule.”Reproduction 164: 9-18 (2022).
  33. Itami C, Uesaka N, Huang JY, Lu HC, Sakimura K, Kano M, Kimura F. “Endocannabinoid-dependent formation of columnar axonal projection in the mouse cerebral cortex.” Proc Natl Acad Sci U S A 119: e2122700119 (2022).